Background and Objective:Virtual reality is a computer technology that places the user in a three-dimensional environment other than their current location. Users can immerse themselves in this environment. It seems that this can help to reduce depression, which is one of the most common mental disorders and a major risk factor for disability and death in humans. Therefore, the aim of the present study was to investigate the effect of virtual reality on the severity of depression. Methods:The present study is a review article. In the first step, a search was conducted in the PubMed, Cochrane Library, Science Direct, Embase, CINHAl, Magiran, SID, and Irandoc databases from 2013 to 2023. The English keywords included: (("Virtual Reality"[Mesh]) or " Immersive Virtual Reality") and ("Depression"[Mesh] or "Depressive Disorder"[Mesh] or "Depressed") and the Persian keywords included: virtual reality, immersive virtual reality, depression. During the initial search, 90 articles were found, of which 15 articles were finally included in the study due to their relevance to the research objective after applying the inclusion and exclusion criteria. Findings:This study showed that natural landscapes (garden, forest, lawn), various games, rehabilitation exercise designs, personalized scenarios, and education through virtual reality can have a positive effect on reducing depression. Conclusion:According to the results of this study, different virtual reality scenarios can be used as an easy, affordable, cost-effective and accessible solution to reduce depression.